LC-APCI-MS-MS methodology for determination of glybenclamide in human plasma
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منابع مشابه
Determination of Etoricoxib in Human Plasma Using Automated On-line Solid-phase Extraction Coupled with Lc-apci/ms/ms
A liquid chromatography-tandem mass spectrometry method with atmospheric pressure chemical ionization (LC-APCI/MS/MS) was validated for the determination of etoricoxib in human plasma using antipyrin as internal standard, followed by on-line solidphase extraction. The method was performed on a Luna C 18 column and the mobile phase consisted of acetonitrile:water (95:5, v/ v)/ammonium acetate (p...
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A highly sensitive liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method is developed to quantitate phenacetin and its metabolite paracetamol in rabbit plasma. The analytes and internal standard oxazepam are extracted from plasma by liquid–liquid extraction using ethyl acetate, and separated on a Zorbax SB-C18 column (2.1 mm 9 150 mm, 5 lm) using aceto...
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Endogenous corticosterone in rodent's hair would be a potential biomarker to assess the response of the hypothalamus-pituitary-adrenal axis to chronic stress. However, currently unknown is whether hair corticosterone is associated with endogenous corticosterone in blood and brain. The present study aimed to develop an enhanced assay for determination of endogenous corticosterone in blood, brain...
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PURPOSE A sensitive, robust, and selective liquid chromatographic-tandem mass spectrometric method (LC-MS/MS) was developed and validated for paroxetine quantification in human EDTA plasma. METHODS Sample preparation was based on liquid-liquid extraction using a mixture of ethyl acetate/hexane (50/50; v/v) to extract the drug and internal standard from plasma. Chromatography was performed on ...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2004
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-004-2610-5